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CNDP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96KN2 |
| Other Accession | Q66HG3, Q8BUG2, NP_116038.4 |
| Reactivity | Human |
| Predicted | Mouse, Rat |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 56692 Da |
| Antigen Region | 142-170 aa |
| Gene ID | 84735 |
|---|---|
| Other Names | Beta-Ala-His dipeptidase, CNDP dipeptidase 1, Carnosine dipeptidase 1, Glutamate carboxypeptidase-like protein 2, Serum carnosinase, CNDP1, CN1, CPGL2 |
| Target/Specificity | This CNDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 142-170 amino acids from the Central region of human CNDP1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | CNDP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | CNDP1 (HGNC:20675) |
|---|---|
| Synonyms | CN1, CPGL2 |
| Function | Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L- histidine) and anserine (beta-alanyl-3-methyl-histidine). |
| Cellular Location | Secreted. |
| Tissue Location | Found in serum and adult nervous central system. Absent in serum from patients with homocarnosinosis |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the M20 metalloprotease family. The encoded protein is specifically expressed in the brain, is a homodimeric dipeptidase which was identified as human carnosinase. This gene contains trinucleotide (CTG) repeat length polymorphism in the coding region.
References
Alkhalaf, A., et al. Diabetologia (2010) In press :
Riedl, E., et al. Diabetes 59(8):1984-1990(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Mooyaart, A.L., et al. Diabetes 59(6):1555-1559(2010)
Kim, S., et al. Clin J Am Soc Nephrol 5(6):1072-1078(2010)
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