|Application ||WB, E|
|Calculated MW||70215 Da|
|Antigen Region||161-189 aa|
|Other Names||Amiloride-sensitive sodium channel subunit delta, Delta-NaCH, Epithelial Na(+) channel subunit delta, Delta-ENaC, ENaCD, Nonvoltage-gated sodium channel 1 subunit delta, SCNED, SCNN1D, DNACH|
|Target/Specificity||This SCNN1D antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 amino acids from the N-terminal region of human SCNN1D.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SCNN1D Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Wesch, D., et al. Am. J. Physiol., Cell Physiol. 299 (4), C779-C790 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Bangel-Ruland, N., et al. Am. J. Respir. Cell Mol. Biol. 42(4):498-505(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Haerteis, S., et al. J. Biol. Chem. 284(42):29024-29040(2009)
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