|Application ||WB, E|
|Calculated MW||82280 Da|
|Antigen Region||127-155 aa|
|Other Names||Zinc finger protein 224, Bone marrow zinc finger 2, BMZF-2, Zinc finger protein 233, Zinc finger protein 255, Zinc finger protein 27, Zinc finger protein KOX22, ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27|
|Target/Specificity||This ZNF224 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the N-terminal region of human ZNF224.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF224 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BMZF2, KOX22, ZNF233, ZNF255, ZNF27|
|Function||May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.|
|Cellular Location||Nucleus Note=Colocalizes with DEPDC1A at the nucleus|
|Tissue Location||Ubiquitous. Mainly expressed in fetal tissues.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ZNF224 may be involved in transcriptional regulation as a transcriptional repressor.
Harada, Y., et al. Cancer Res. 70(14):5829-5839(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Shulman, J.M., et al. PLoS ONE 5 (6), E11244 (2010) :
Cesaro, E., et al. J. Biol. Chem. 284(47):32321-32330(2009)
Iacobazzi, V., et al. Biochem. Biophys. Res. Commun. 386(1):186-191(2009)
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