|Application ||WB, E|
|Calculated MW||82280 Da|
|Antigen Region||127-155 aa|
|Other Names||Zinc finger protein 224, Bone marrow zinc finger 2, BMZF-2, Zinc finger protein 233, Zinc finger protein 255, Zinc finger protein 27, Zinc finger protein KOX22, ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27|
|Target/Specificity||This ZNF224 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 127-155 amino acids from the N-terminal region of human ZNF224.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF224 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||BMZF2, KOX22, ZNF233, ZNF255, ZNF27|
|Function||May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.|
|Cellular Location||Nucleus Note=Colocalizes with DEPDC1A at the nucleus|
|Tissue Location||Ubiquitous. Mainly expressed in fetal tissues.|
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Provided below are standard protocols that you may find useful for product applications.
ZNF224 may be involved in transcriptional regulation as a transcriptional repressor.
Harada, Y., et al. Cancer Res. 70(14):5829-5839(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Shulman, J.M., et al. PLoS ONE 5 (6), E11244 (2010) :
Cesaro, E., et al. J. Biol. Chem. 284(47):32321-32330(2009)
Iacobazzi, V., et al. Biochem. Biophys. Res. Commun. 386(1):186-191(2009)
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