|Application ||WB, E|
|Calculated MW||87199 Da|
|Antigen Region||781-808 aa|
|Other Names||TBC1 domain family member 10B, Rab27A-GAP-beta, TBC1D10B|
|Target/Specificity||This TBC1D10B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 781-808 amino acids from the C-terminal region of human TBC1D10B.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TBC1D10B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Acts as GTPase-activating protein for RAB3A, RAB22A, RAB27A, AND RAB35. Does not act on RAB2A and RAB6A.|
|Cellular Location||Cytoplasm. Note=In melanocytes, located at the periphery of cells|
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Provided below are standard protocols that you may find useful for product applications.
Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)
Choy, K.W., et al. Physiol. Genomics 25(1):9-15(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
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