TBC1D10B Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q4KMP7 |
Other Accession | NP_056342.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 87199 Da |
Antigen Region | 781-808 aa |
Gene ID | 26000 |
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Other Names | TBC1 domain family member 10B, Rab27A-GAP-beta, TBC1D10B |
Target/Specificity | This TBC1D10B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 781-808 amino acids from the C-terminal region of human TBC1D10B. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | TBC1D10B Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | TBC1D10B |
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Function | Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A. |
Cellular Location | Cytoplasm. Note=In melanocytes, located at the periphery of cells |
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Provided below are standard protocols that you may find useful for product applications.
Background
Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).
References
Ishibashi, K., et al. Genes Cells 14(1):41-52(2009)
Choy, K.W., et al. Physiol. Genomics 25(1):9-15(2006)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
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