|Application ||WB, E|
|Calculated MW||27324 Da|
|Antigen Region||146-173 aa|
|Other Names||C-type lectin domain family 9 member A, CLEC9A|
|Target/Specificity||This CLEC9A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-173 amino acids from the Central region of human CLEC9A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CLEC9A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).
Poulin, L.F., et al. J. Exp. Med. 207(6):1261-1271(2010)
Sancho, D., et al. Nature 458(7240):899-903(2009)
Caminschi, I., et al. Blood 112(8):3264-3273(2008)
Huysamen, C., et al. J. Biol. Chem. 283(24):16693-16701(2008)
Sancho, D., et al. J. Clin. Invest. 118(6):2098-2110(2008)
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