CLEC9A Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q6UXN8 |
Other Accession | NP_997228.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 27324 Da |
Antigen Region | 146-173 aa |
Gene ID | 283420 |
---|---|
Other Names | C-type lectin domain family 9 member A, CLEC9A |
Target/Specificity | This CLEC9A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-173 amino acids from the Central region of human CLEC9A. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CLEC9A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CLEC9A |
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Function | Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. |
Cellular Location | Membrane; Single- pass type II membrane protein |
Tissue Location | In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes. |
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Provided below are standard protocols that you may find useful for product applications.
Background
CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).
References
Poulin, L.F., et al. J. Exp. Med. 207(6):1261-1271(2010)
Sancho, D., et al. Nature 458(7240):899-903(2009)
Caminschi, I., et al. Blood 112(8):3264-3273(2008)
Huysamen, C., et al. J. Biol. Chem. 283(24):16693-16701(2008)
Sancho, D., et al. J. Clin. Invest. 118(6):2098-2110(2008)
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