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CLEC9A Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - CLEC9A Antibody (Center) AP17684c
    CLEC9A Antibody (Center) (Cat. #AP17684c) western blot analysis in ZR-75-1 cell line lysates (35ug/lane).This demonstrates the CLEC9A antibody detected the CLEC9A protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q6UXN8
Other Accession NP_997228.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 27324 Da
Antigen Region 146-173 aa
Additional Information
Gene ID 283420
Other Names C-type lectin domain family 9 member A, CLEC9A
Target/Specificity This CLEC9A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 146-173 amino acids from the Central region of human CLEC9A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCLEC9A Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name CLEC9A
Function Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.
Cellular Location Membrane; Single- pass type II membrane protein
Tissue Location In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.
Research Areas
Citations (0)
citation

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Background

CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).

References

Poulin, L.F., et al. J. Exp. Med. 207(6):1261-1271(2010)
Sancho, D., et al. Nature 458(7240):899-903(2009)
Caminschi, I., et al. Blood 112(8):3264-3273(2008)
Huysamen, C., et al. J. Biol. Chem. 283(24):16693-16701(2008)
Sancho, D., et al. J. Clin. Invest. 118(6):2098-2110(2008)

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$ 365.00
$ 140.00
Cat# AP17684c
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