|Application ||WB, E|
|Calculated MW||74077 Da|
|Antigen Region||12-40 aa|
|Other Names||Fidgetin-like protein 1, 364-, FIGNL1|
|Target/Specificity||This FIGNL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human FIGNL1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FIGNL1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX- dependent manner. May regulate osteoblast proliferation and differentiation.|
|Cellular Location||Nucleus. Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment|
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Provided below are standard protocols that you may find useful for product applications.
FIGNL1 may regulate osteoblast proliferation and differentiation (By similarity).
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
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