|Application ||WB, E|
|Antigen Region||64-92 aa|
|Other Names||39S ribosomal protein L54, mitochondrial, L54mt, MRP-L54, MRPL54|
|Target/Specificity||This MRPL54 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 64-92 amino acids from the Central region of human MRPL54.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MRPL54 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Mitochondrion. EMBL; BC065273; AAH65273.1; -; mRNA CCDS; CCDS12111.1; - RefSeq; NP_758455.1; NM_172251.2 UniGene; Hs.356578; - PDB; 3J9M; EM; 3.50 A; l=1-138 PDBsum; 3J9M; - ProteinModelPortal; Q6P161; - SMR; Q6P161; - BioGrid; 125522; 13 IntAct; Q6P161; 8 STRING; 9606.ENSP00000331849; - BioMuta; MRPL54; - DMDM; 74737109; - EPD; Q6P161; - MaxQB; Q6P161; - PaxDb; Q6P161; - PeptideAtlas; Q6P161; - PRIDE; Q6P161; - TopDownProteomics; Q6P161; - DNASU; 116541; - Ensembl; ENST00000330133; ENSP00000331849; ENSG00000183617 GeneID; 116541; - KEGG; hsa:116541; - UCSC; uc002lyq.5; human CTD; 116541; - GeneCards; MRPL54; - HGNC; HGNC:16685; MRPL54 HPA; HPA042117; - HPA; HPA046767; - MIM; 611858; gene neXtProt; NX_Q6P161; - OpenTargets; ENSG00000183617; - PharmGKB; PA30987; - eggNOG; KOG3435; Eukaryota eggNOG; ENOG411244M; LUCA GeneTree; ENSGT00390000001201; - HOGENOM; HOG000068097; - HOVERGEN; HBG093903; - InParanoid; Q6P161; - KO; K17435; - OMA; RLTTYAM; - OrthoDB; EOG091G0TM2; - PhylomeDB; Q6P161; - TreeFam; TF314007; - BioCyc; ZFISH:G66-32467-MONOMER; - Reactome; R-HSA-5368286; Mitochondrial translation initiation Reactome; R-HSA-5389840; Mitochondrial translation elongation Reactome; R-HSA-5419276; Mitochondrial translation termination GenomeRNAi; 116541; - PRO; PR:Q6P161; - Proteomes; UP000005640; Chromosome 19 Bgee; ENSG00000183617; - CleanEx; HS_MRPL54; - ExpressionAtlas; Q6P161; baseline and differential Genevisible; Q6P161; HS GO; GO:0005743; C:mitochondrial inner membrane; TAS:Reactome GO; GO:0005762; C:mitochondrial large ribosomal subunit; IDA:UniProtKB GO; GO:0044822; F:poly(A) RNA binding; IDA:UniProtKB GO; GO:0070125; P:mitochondrial translational elongation; TAS:Reactome GO; GO:0070126; P:mitochondrial translational termination; TAS:Reactome InterPro; IPR013870; Ribosomal_L37_mit Pfam; PF08561; Ribosomal_L37; 1 1: Evidence at protein level; 3D-structure; Complete proteome; Mitochondrion; Reference proteome; Ribonucleoprotein; Ribosomal protein; Transit peptide TRANSIT 1 14 Mitochondrion. CHAIN 15 138 39S ribosomal protein L54, mitochondrial /FTId=PRO_0000278280 SEQUENCE 138 AA; 15819 MW; 98E0FCA10592B064 CRC64; MATKRLFGAT RTWAGWGAWE LLNPATSGRL LARDYAKKPV MKGAKSGKGA VTSEALKDPD VCTDPVQLTT YAMGVNIYKE GQDVPLKPDA EYPEWLFEMN LGPPKTLEEL DPESREYWRR LRKQNIWRHN RLSKNKRL|
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Provided below are standard protocols that you may find useful for product applications.
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq].
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Zhang, Z., et al. Genomics 81(5):468-480(2003)
Koc, E.C., et al. J. Biol. Chem. 276(47):43958-43969(2001)
Adams, M.D., et al. Nature 377 (6547 SUPPL), 3-174 (1995) :
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