|Application ||WB, E|
|Calculated MW||78636 Da|
|Antigen Region||671-699 aa|
|Other Names||PWWP domain-containing protein MUM1, Mutated melanoma-associated antigen 1, MUM-1, Protein expandere, MUM1, EXPAND1|
|Target/Specificity||This MUM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 671-699 amino acids from the C-terminal region of human MUM1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MUM1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.|
|Cellular Location||Nucleus. Note=Recruited to DNA damage sites via its interaction with the BRCT domain of TP53BP1|
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage.
Huen, M.S., et al. Mol. Cell 37(6):854-864(2010)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Coulie, P.G., et al. Proc. Natl. Acad. Sci. U.S.A. 92(17):7976-7980(1995)
If you have any additional inquiries please email technical services at firstname.lastname@example.org.