|Application ||WB, E|
|Other Accession||P70061, P97503, NP_001180.1|
|Calculated MW||34814 Da|
|Antigen Region||3-2 aa|
|Other Names||Homeobox protein Nkx-32, Bagpipe homeobox protein homolog 1, Homeobox protein NK-3 homolog B, NKX3-2, BAPX1, NKX3B|
|Target/Specificity||This NKX3-2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-235 amino acids from the Central region of human NKX3-2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NKX3-2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional repressor that acts as a negative regulator of chondrocyte maturation. PLays a role in distal stomach development; required for proper antral-pyloric morphogenesis and development of antral-type epithelium. In concert with GSC, defines the structural components of the middle ear; required for tympanic ring and gonium development and in the regulation of the width of the malleus (By similarity).|
|Tissue Location||Expressed at highest levels in cartilage, bone (osteosarcoma) and gut (small intestine and colon), whereas moderate expression is seen in trachea and brain. Expressed in visceral mesoderm and embryonic skeleton|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the NK family of homeobox-containing proteins. The encoded protein may play a role in skeletal development.
Hellemans, J., et al. Am. J. Hum. Genet. 85(6):916-922(2009)
Rodrigo, I., et al. Mol. Cell. Biol. 24(7):2757-2766(2004)
Tribioli, C., et al. Gene 203(2):225-233(1997)
Yoshiura, K.I., et al. Genomics 45(2):425-428(1997)
Tribioli, C., et al. Mech. Dev. 65 (1-2), 145-162 (1997) :
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