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OTOP2 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - OTOP2 Antibody (Center) AP17704C
    OTOP2 Antibody (Center) (Cat. #AP17704c) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the OTOP2 antibody detected the OTOP2 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q7RTS6
Other Accession Q80SX5, NP_835454.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 62236 Da
Antigen Region 336-363 aa
Additional Information
Gene ID 92736
Other Names Otopetrin-2, OTOP2
Target/Specificity This OTOP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 336-363 amino acids from the Central region of human OTOP2.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsOTOP2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name OTOP2 {ECO:0000303|PubMed:12651873, ECO:0000312|HGNC:HGNC:19657}
Function Proton-selective channel that specifically transports protons into cells. Proton-selective channel activity is probably required in cell types that use changes in intracellular pH for cell signaling or to regulate biochemical or developmental processes.
Cellular Location Cell membrane {ECO:0000250|UniProtKB:Q80VM9}; Multi-pass membrane protein
Research Areas
Citations (0)

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Otopetrins are multi-transmembrane domain proteins that share conserved gene and protein structure and are possibly involved in the formation of otoconia and otoliths. Located in the utricle and saccule of the inner ear, otoconia are complex calcium carbonate biominerals that are required for the normal sensation of gravity and linear acceleration. Vertigo and loss of balance may be attributed to degeneration of displacement of otoconia. The otopetrin family consists of three proteins, OTOP1, OTOP2 and OTOP3. These proteins have 12 putative transmembrane domains that are clustered into three otopetrin domains (OD-I, II and III). OTOP1 was the first described member of the Otopetrin family. Mutations of OTOP1 leads to absence of otoconia or otoliths, though inner ear development is normal. OTOP2 and OTOP3 share significant structural similarity with OTOP1 and may also play a role in the formation of mineralized structures.


Hurle, B., et al. Hum. Mol. Genet. 12(7):777-789(2003)

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$ 295.00
$ 99.00
Cat# AP17704C
(40 western blots)
Availability: In Stock
Bulk Size
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