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TMED1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q13445 |
| Other Accession | Q2TBK5, NP_006849.1 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 25206 Da |
| Antigen Region | 77-104 aa |
| Gene ID | 11018 |
|---|---|
| Other Names | Transmembrane emp24 domain-containing protein 1, Interleukin-1 receptor-like 1 ligand, Putative T1/ST2 receptor-binding protein, p24 family protein gamma-1, Tp24, p24gamma1, TMED1, IL1RL1L, IL1RL1LG |
| Target/Specificity | This TMED1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 77-104 amino acids from the Central region of human TMED1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TMED1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TMED1 |
|---|---|
| Synonyms | IL1RL1L, IL1RL1LG |
| Function | Potential role in vesicular protein trafficking, mainly in the early secretory pathway. May act as a cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and may be involved in vesicle coat formation at the cytoplasmic side. Plays a positive role in IL-33-mediated IL-8 and IL-6 production by interacting with interleukin-33 receptor IL1RL1 (PubMed:23319592). Also plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26 (PubMed:32614325). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein |
| Tissue Location | Widely expressed.. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1). This protein lacks any similarity to other interleukin 1 ligands. The functional significance of its interaction with IL1RL1 is not known.
References
Tare, N., et al. Exp. Cell Res. 316(15):2527-2537(2010)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)
Grimwood, J., et al. Nature 428(6982):529-535(2004)
Gayle, M.A., et al. J. Biol. Chem. 271(10):5784-5789(1996)
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