|Application ||WB, E|
|Other Accession||Q9Z118, Q8BHD7, NP_001157262.1, NP_005147.3|
|Calculated MW||59690 Da|
|Antigen Region||253-279 aa|
|Other Names||Polypyrimidine tract-binding protein 3, Regulator of differentiation 1, Rod1, PTBP3, ROD1|
|Target/Specificity||This ROD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 253-279 amino acids from the N-terminal region of human ROD1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ROD1 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein that mediates pre-mRNA alternative splicing regulation. Plays a role in the regulation of cell proliferation, differentiation and migration. Positive regulator of EPO-dependent erythropoiesis. Participates in cell differentiation regulation by repressing tissue-specific exons. Promotes FAS exon 6 skipping. Binds RNA, preferentially to both poly(G) and poly(U).|
|Tissue Location||Expressed in several hematopoietic cell lines examined.|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
ROD1 is a functional homolog of nrd1, an S. pombe RNA-binding protein that suppresses the onset of differentiation.
Rose, J. Phd, et al. Mol. Med. (2010) In press :
Sadvakassova, G., et al. J. Cell. Physiol. 220(3):672-679(2009)
Yamamoto, H., et al. Mol. Cell. Biol. 19(5):3829-3841(1999)
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