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HMGB4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
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- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q8WW32 |
| Other Accession | Q32L34 |
| Reactivity | Human |
| Predicted | Bovine |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 22490 Da |
| Antigen Region | 45-73 aa |
| Gene ID | 127540 |
|---|---|
| Other Names | High mobility group protein B4, HMGB4 |
| Target/Specificity | This HMGB4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 45-73 amino acids from the Central region of human HMGB4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | HMGB4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | HMGB4 |
|---|---|
| Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q6P8W9}. Chromosome {ECO:0000250|UniProtKB:Q6P8W9}. Note=Interacts specifically with the sex chromosomes. {ECO:0000250|UniProtKB:Q6P8W9} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
High Mobility Group (HMG) proteins, a group of chromosomal proteins common to all eukaryotes, bind DNA in a non-sequence-specific fashion to promote chromatin function and gene regulation, helping with transcription, replication, recombination, and DNA repair. HMGB4 is HMG2-like, isoform 2, high-mobility group box 4. This gene can be found on Chromosome 1. HMGB4 contains two HMG-box regions, and is found in a variety of eukaryotic chromosomal proteins. HMGB proteins are phosphorylated to various extents. The existence of differentially modified forms increases the number of distinct HMGB protein variants in plant chromatin that may be adapted to certain functions.
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