|Application ||WB, E|
|Other Accession||Q5BKR2, NP_849155.2|
|Calculated MW||57564 Da|
|Antigen Region||458-486 aa|
|Other Names||Mitochondrial sodium/hydrogen exchanger 9B2, Mitochondrial Na(+)/H(+) exchanger NHA2, Na(+)/H(+) exchanger-like domain-containing protein 2, NHE domain-containing protein 2, Sodium/hydrogen exchanger-like domain-containing protein 2, Solute carrier family 9 subfamily B member 2, SLC9B2, NHA2, NHEDC2|
|Target/Specificity||This NHEDC2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-486 amino acids from the C-terminal region of human NHEDC2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||NHEDC2 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Electroneutral exchange of protons for Na(+) and Li(+) across the inner mitochondrial membrane. Contributes to the organellar volume homeostasis. Required for osteoclast differentiation and bone resorption activity (By similarity).|
|Cellular Location||Mitochondrion membrane; Multi- pass membrane protein|
|Tissue Location||Detected in red blood cells (at protein level)|
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Provided below are standard protocols that you may find useful for product applications.
Sodium hydrogen antiporters, such as NHEDC2, convert the proton motive force established by the respiratory chain or the F1F0 mitochondrial ATPase into sodium gradients that drive other energy-requiring processes, transduce environmental signals into cell responses, or function in drug efflux (Xiang et al., 2007 [PubMed 18000046]).
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Schushan, M., et al. J. Mol. Biol. 396(5):1181-1196(2010)
Fuster, D.G., et al. J. Am. Soc. Nephrol. 19(8):1547-1556(2008)
Battaglino, R.A., et al. Bone 42(1):180-192(2008)
Xiang, M., et al. Proc. Natl. Acad. Sci. U.S.A. 104(47):18677-18681(2007)
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