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TCERG1 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O14776 |
| Other Accession | Q8CGF7, NP_006697.2, NP_001035095.1 |
| Reactivity | Human |
| Predicted | Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 123901 Da |
| Antigen Region | 991-1020 aa |
| Gene ID | 10915 |
|---|---|
| Other Names | Transcription elongation regulator 1, TATA box-binding protein-associated factor 2S, Transcription factor CA150, TCERG1, CA150, TAF2S |
| Target/Specificity | This TCERG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 991-1020 amino acids from the C-terminal region of human TCERG1. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | TCERG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | TCERG1 |
|---|---|
| Synonyms | CA150, TAF2S |
| Function | Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter. |
| Cellular Location | Nucleus |
| Tissue Location | Detected in brain neurons. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.
References
Sanchez-Alvarez, M., et al. J. Biol. Chem. 285(20):15220-15233(2010)
Koskinen, L.L., et al. Tissue Antigens 74(5):408-416(2009)
Murphy, J.M., et al. J. Mol. Biol. 393(2):409-424(2009)
Lu, M., et al. J. Mol. Biol. 393(2):397-408(2009)
Pearson, J.L., et al. J. Biol. Chem. 283(12):7949-7961(2008)
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