|Application ||WB, E|
|Other Accession||Q8CGF7, NP_006697.2, NP_001035095.1|
|Calculated MW||123901 Da|
|Antigen Region||991-1020 aa|
|Other Names||Transcription elongation regulator 1, TATA box-binding protein-associated factor 2S, Transcription factor CA150, TCERG1, CA150, TAF2S|
|Target/Specificity||This TCERG1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 991-1020 amino acids from the C-terminal region of human TCERG1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||TCERG1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.|
|Tissue Location||Detected in brain neurons.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing factor SF1 via a WW domain. Alternative splicing results in multiple transcripts variants encoding different isoforms.
Sanchez-Alvarez, M., et al. J. Biol. Chem. 285(20):15220-15233(2010)
Koskinen, L.L., et al. Tissue Antigens 74(5):408-416(2009)
Murphy, J.M., et al. J. Mol. Biol. 393(2):409-424(2009)
Lu, M., et al. J. Mol. Biol. 393(2):397-408(2009)
Pearson, J.L., et al. J. Biol. Chem. 283(12):7949-7961(2008)
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