SLFN12 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q8IYM2 |
Other Accession | NP_060512.3 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 66972 Da |
Antigen Region | 192-220 aa |
Gene ID | 55106 |
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Other Names | Schlafen family member 12, SLFN12 |
Target/Specificity | This SLFN12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 192-220 amino acids from the Central region of human SLFN12. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SLFN12 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SLFN12 (HGNC:25500) |
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Function | Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling (PubMed:31420216, PubMed:35104454, PubMed:34272366, PubMed:34707099). May play a role in cell differentiation (PubMed:30045019). |
Cellular Location | Nucleus. Cytoplasm, cytosol |
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Provided below are standard protocols that you may find useful for product applications.
Background
Belongs to the Schlafen family.
References
Schwarz, D.A., et al. Immunity 9(5):657-668(1998)
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