|Application ||WB, E|
|Calculated MW||31264 Da|
|Antigen Region||183-211 aa|
|Other Names||OX-2 membrane glycoprotein, CD200, CD200, MOX1, MOX2|
|Target/Specificity||This CD200 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 183-211 amino acids from the C-terminal region of human CD200.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||CD200 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues.|
|Cellular Location||Cell membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.
Dorfman, D.M., et al. Am. J. Clin. Pathol. 134(5):726-733(2010)
Wong, K.K., et al. J. Leukoc. Biol. 88(2):361-372(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Koning, N., et al. J Innate Immun 2(2):195-200(2010)
Rittie, L., et al. Aging Cell 8(6):738-751(2009)
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