SRGAP1 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
---|---|
Primary Accession | Q7Z6B7 |
Other Accession | NP_065813.1 |
Reactivity | Human, Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 124264 Da |
Antigen Region | 469-497 aa |
Gene ID | 57522 |
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Other Names | SLIT-ROBO Rho GTPase-activating protein 1, srGAP1, Rho GTPase-activating protein 13, SRGAP1, ARHGAP13, KIAA1304 |
Target/Specificity | This SRGAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 469-497 amino acids from the Central region of human SRGAP1. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SRGAP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SRGAP1 |
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Synonyms | ARHGAP13, KIAA1304 |
Function | GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. |
Tissue Location | Expressed in brain, lung, kidney, and testis. |
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Provided below are standard protocols that you may find useful for product applications.
Background
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Voss, M., et al. BMC Immunol. 10, 53 (2009) :
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Olsen, J.V., et al. Cell 127(3):635-648(2006)
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
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