|Application ||WB, E|
|Calculated MW||19046 Da|
|Antigen Region||106-134 aa|
|Other Names||Platelet glycoprotein IX, GP-IX, GPIX, Glycoprotein 9, CD42a, GP9|
|Target/Specificity||This GP9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from the C-terminal region of human GP9.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GP9 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The GPIb-V-IX complex functions as the vWF receptor and mediates vWF-dependent platelet adhesion to blood vessels. The adhesion of platelets to injured vascular surfaces in the arterial circulation is a critical initiating event in hemostasis. GP-IX may provide for membrane insertion and orientation of GP-Ib.|
|Cellular Location||Membrane; Single-pass type I membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq].
Munday, A.D., et al. J. Thromb. Haemost. 8(1):163-172(2010)
Mo, X., et al. J. Thromb. Haemost. 7(9):1533-1540(2009)
Mangin, P.H., et al. J. Thromb. Haemost. 7(9):1550-1555(2009)
Strassel, C., et al. Haematologica 94(6):800-810(2009)
Zieger, B., et al. Hamostaseologie 29(2):161-167(2009)
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