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SIX6 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | O95475 |
| Other Accession | Q9QZ28, O93307, Q62233, O95343, O42406, NP_031400.2 |
| Reactivity | Human, Mouse |
| Predicted | Chicken |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 27687 Da |
| Antigen Region | 96-124 aa |
| Gene ID | 4990 |
|---|---|
| Other Names | Homeobox protein SIX6, Homeodomain protein OPTX2, Optic homeobox 2, Sine oculis homeobox homolog 6, SIX6, OPTX2, SIX9 |
| Target/Specificity | This SIX6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-124 amino acids from the Central region of human SIX6. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | SIX6 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | SIX6 |
|---|---|
| Synonyms | OPTX2, SIX9 |
| Function | May be involved in eye development. |
| Cellular Location | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
| Tissue Location | Expressed in the developing and adult retina. Also expressed in the hypothalamic and the pituitary regions |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in eye development. Defects in this gene are a cause of isolated microphthalmia with cataract type 2 (MCOPCT2).
References
Zhang, X., et al. Mol. Vis. 15, 2911-2918 (2009) :
Ou, Z., et al. Am. J. Med. Genet. A 146A (19), 2480-2489 (2008) :
Hu, S., et al. Biochemistry 47(11):3586-3594(2008)
Aijaz, S., et al. Invest. Ophthalmol. Vis. Sci. 45(11):3871-3876(2004)
Gallardo, M.E., et al. Am. J. Med. Genet. A 129A (1), 92-94 (2004) :
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