RAB39B Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q96DA2 |
Other Accession | Q8BHC1, Q17QU4, NP_741995.1 |
Reactivity | Human, Mouse |
Predicted | Bovine |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 24622 Da |
Antigen Region | 12-40 aa |
Gene ID | 116442 |
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Other Names | Ras-related protein Rab-39B, RAB39B |
Target/Specificity | This RAB39B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human RAB39B. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | RAB39B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | RAB39B |
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Function | Small GTPases Rab involved in autophagy (PubMed:27103069). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27103069). May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post- synapses and thus synaptic transmission (By similarity). |
Cellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus Note=Partial colocalization with markers that cycle from the cell surface to the trans-Golgi network. {ECO:0000250|UniProtKB:Q8BHC1} |
Tissue Location | Highly expressed in the brain. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking.
References
Giannandrea, M., et al. Am. J. Hum. Genet. 86(2):185-195(2010)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Cheng, H., et al. Cytogenet. Genome Res. 97 (1-2), 72-75 (2002) :
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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