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RAB39B Antibody (N-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RAB39B Antibody (N-term) AP17799A
    RAB39B Antibody (N-term) (Cat. #AP17799a) western blot analysis in mouse NIH-3T3 cell line lysates (35ug/lane).This demonstrates the RAB39B antibody detected the RAB39B protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q96DA2
Other Accession Q8BHC1, Q17QU4, NP_741995.1
Reactivity Human, Mouse
Predicted Bovine
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 24622 Da
Antigen Region 12-40 aa
Additional Information
Gene ID 116442
Other Names Ras-related protein Rab-39B, RAB39B
Target/Specificity This RAB39B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human RAB39B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAB39B Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB39B
Function Small GTPases Rab involved in autophagy (PubMed:27103069). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27103069). May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post- synapses and thus synaptic transmission (By similarity).
Cellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus Note=Partial colocalization with markers that cycle from the cell surface to the trans-Golgi network. {ECO:0000250|UniProtKB:Q8BHC1}
Tissue Location Highly expressed in the brain.
Research Areas
Citations (0)
citation

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Background

This gene encodes a member of the Rab family of proteins. Rab proteins are small GTPases that are involved in vesicular trafficking.

References

Giannandrea, M., et al. Am. J. Hum. Genet. 86(2):185-195(2010)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
Cheng, H., et al. Cytogenet. Genome Res. 97 (1-2), 72-75 (2002) :
Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)

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$ 182.50
$ 70.00
Cat# AP17799A
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