|Application ||WB, E|
|Other Accession||Q921F4, NP_612403.2|
|Calculated MW||60083 Da|
|Antigen Region||132-162 aa|
|Other Names||Heterogeneous nuclear ribonucleoprotein L-like, hnRNPLL, Stromal RNA-regulating factor, HNRNPLL, HNRPLL, SRRF|
|Target/Specificity||This HNRPLL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 132-162 amino acids from the N-terminal region of human HNRPLL.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||HNRPLL Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||RNA-binding protein that functions as regulator of alternative splicing for multiple target mRNAs, including PTPRC/CD45 and STAT5A. Required for alternative splicing of PTPRC.|
|Tissue Location||Widely expressed. Detected in bone marrow stroma cells, skeletal muscle, heart, placenta, pancreas, kidney and lung.|
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Provided below are standard protocols that you may find useful for product applications.
HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).
Wu, Z., et al. J. Immunol. 185(1):231-238(2010)
Topp, J.D., et al. RNA 14(10):2038-2049(2008)
Oberdoerffer, S., et al. Science 321(5889):686-691(2008)
Lim, J., et al. Cell 125(4):801-814(2006)
Andersen, J.S., et al. Nature 433(7021):77-83(2005)
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