|Application ||WB, E|
|Other Accession||Q8VD12, NP_001124439.1|
|Calculated MW||40454 Da|
|Antigen Region||57-83 aa|
|Other Names||Zinc finger protein 385A, Hematopoietic zinc finger protein, Retinal zinc finger protein, ZNF385A, HZF, RZF, ZNF385|
|Target/Specificity||This ZNF385A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-83 amino acids from the N-terminal region of human ZNF385A.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ZNF385A Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Synonyms||HZF, RZF, ZNF385|
|Function||RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti- proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation.|
|Cellular Location||Cytoplasm. Nucleus, nucleolus. Cell projection, dendrite. Note=Detected in dendrites of Purkinje cells and hippocampal neurons.|
|Tissue Location||Expressed predominantly in the retina.|
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Provided below are standard protocols that you may find useful for product applications.
Zinc finger proteins, such as ZNF385A, are regulatory proteins that act as transcription factors, bind single- or double-stranded RNA, or interact with other proteins (Sharma et al., 2004 [PubMed 15527981]).
Das, S., et al. Cell 130(4):624-637(2007)
Sharma, S., et al. Gene 342(2):219-229(2004)
Kimura, Y., et al. J. Exp. Med. 195(7):941-952(2002)
Hidaka, M., et al. Mech. Dev. 90(1):3-15(2000)
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