|Application ||WB, E|
|Calculated MW||36961 Da|
|Antigen Region||97-122 aa|
|Other Names||ALX homeobox protein 1, Cartilage homeoprotein 1, CART-1, ALX1, CART1|
|Target/Specificity||This ALX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 97-122 amino acids from the Central region of human ALX1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALX1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Sequence-specific DNA-binding transcription factor that binds palindromic sequences within promoters and may activate or repress the transcription of a subset of genes (PubMed:9753625, PubMed:8756334). Most probably regulates the expression of genes involved in the development of mesenchyme-derived craniofacial structures. Early on in development, it plays a role in forebrain mesenchyme survival (PubMed:20451171). May also induce epithelial to mesenchymal transition (EMT) through the expression of SNAI1 (PubMed:23288509).|
|Tissue Location||Cartilage and cervix tissue.|
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Provided below are standard protocols that you may find useful for product applications.
The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly. [provided by RefSeq].
Uz, E., et al. Am. J. Hum. Genet. 86(5):789-796(2010)
Iioka, T., et al. J. Bone Miner. Res. 18(8):1419-1429(2003)
Qu, S., et al. Development 126(2):359-369(1999)
Cai, R.L. Biochem. Biophys. Res. Commun. 250(2):305-311(1998)
Gordon, D.F., et al. DNA Cell Biol. 15(7):531-541(1996)
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