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DR1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - DR1 Antibody (Center) AP17826C
    DR1 Antibody (Center) (Cat. #AP17826c) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the DR1 antibody detected the DR1 protein (arrow).
  • WB - DR1 Antibody (Center) AP17826C
    DR1 Antibody (Center) (Cat. #AP17826c) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the DR1 antibody detected the DR1 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q01658
Other Accession Q5XI68, Q91WV0, Q5ZMV3, NP_001929.1
Reactivity Human, Mouse
Predicted Chicken, Rat
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 19444 Da
Antigen Region 83-112 aa
Additional Information
Gene ID 1810
Other Names Protein Dr1, Down-regulator of transcription 1, Negative cofactor 2-beta, NC2-beta, TATA-binding protein-associated phosphoprotein, DR1
Target/Specificity This DR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the Central region of human DR1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDR1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DR1
Function The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.
Cellular Location Nucleus.
Research Areas
Citations (0)

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This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.


Corneveaux, J.J., et al. Hum. Mol. Genet. 19(16):3295-3301(2010)
Kantidakis, T., et al. Nucleic Acids Res. 38(4):1228-1239(2010)
Albert, T.K., et al. Genome Biol. 11 (3), R33 (2010) :
Kahle, J., et al. J. Biol. Chem. 284(14):9382-9393(2009)
Wang, Y.L., et al. J. Biol. Chem. 283(49):33808-33815(2008)

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$ 295.00
$ 99.00
Cat# AP17826C
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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