|Application ||WB, E|
|Other Accession||Q5XI68, Q91WV0, Q5ZMV3, NP_001929.1|
|Calculated MW||19444 Da|
|Antigen Region||83-112 aa|
|Other Names||Protein Dr1, Down-regulator of transcription 1, Negative cofactor 2-beta, NC2-beta, TATA-binding protein-associated phosphoprotein, DR1|
|Target/Specificity||This DR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 83-112 amino acids from the Central region of human DR1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||DR1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||The association of the DR1/DRAP1 heterodimer with TBP results in a functional repression of both activated and basal transcription of class II genes. This interaction precludes the formation of a transcription-competent complex by inhibiting the association of TFIIA and/or TFIIB with TBP. Can bind to DNA on its own. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription.
Corneveaux, J.J., et al. Hum. Mol. Genet. 19(16):3295-3301(2010)
Kantidakis, T., et al. Nucleic Acids Res. 38(4):1228-1239(2010)
Albert, T.K., et al. Genome Biol. 11 (3), R33 (2010) :
Kahle, J., et al. J. Biol. Chem. 284(14):9382-9393(2009)
Wang, Y.L., et al. J. Biol. Chem. 283(49):33808-33815(2008)
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