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RMND5A Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RMND5A Antibody (C-term) AP17828b
    RMND5A Antibody (C-term) (Cat. #AP17828b) western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the RMND5A antibody detected the RMND5A protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9H871
Other Accession Q6GLP4, Q80YQ8, NP_073617.1
Reactivity Human, Mouse
Predicted Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 43993 Da
Antigen Region 300-327 aa
Additional Information
Gene ID 64795
Other Names Protein RMD5 homolog A, RMND5A
Target/Specificity This RMND5A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 300-327 amino acids from the C-terminal region of human RMND5A.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRMND5A Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RMND5A
Function Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin- protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972).
Cellular Location Nucleus, nucleoplasm. Cytoplasm
Research Areas
Citations (0)
citation

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Background

RMND5A contains one CTLH domain and one LisH domain. There are two isoforms.

References

Kobayashi, N., et al. Gene 396(2):236-247(2007)
Bowzard, J.B., et al. J. Biol. Chem. 282(24):17568-17580(2007)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Colland, F., et al. Genome Res. 14(7):1324-1332(2004)

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$ 365.00
$ 140.00
Cat# AP17828b
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