|Application ||WB, E|
|Calculated MW||77257 Da|
|Antigen Region||348-375 aa|
|Other Names||Sex comb on midleg-like protein 2, SCML2|
|Target/Specificity||This SCML2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 348-375 amino acids from the Central region of human SCML2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SCML2 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development (By similarity).|
|Tissue Location||Highly expressed in placenta, thymus and testis. Detected at lower levels in brain, liver, skeletal muscle, pancreas and ovary.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development.
Santiveri, C.M., et al. J. Mol. Biol. 382(5):1107-1112(2008)
Matsuoka, S., et al. Science 316(5828):1160-1166(2007)
Beausoleil, S.A., et al. Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135(2004)
Sathyamurthy, A., et al. J. Biol. Chem. 278(47):46968-46973(2003)
Montini, E., et al. Genomics 58(1):65-72(1999)
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