|Application ||WB, E|
|Other Accession||Q8BKV0, NP_001035249.1|
|Calculated MW||49429 Da|
|Antigen Region||36-63 aa|
|Other Names||Testican-3, SPARC/osteonectin, CWCV, and Kazal-like domains proteoglycan 3, SPOCK3, TICN3|
|Target/Specificity||This SPOCK3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 36-63 amino acids from the N-terminal region of human SPOCK3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||SPOCK3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May participate in diverse steps of neurogenesis. Inhibits the processing of pro-matrix metalloproteinase 2 (MMP-2) by MT1-MMP and MT3-MMP. May interfere with tumor invasion.|
|Cellular Location||Secreted, extracellular space, extracellular matrix|
|Tissue Location||Expressed in brain.|
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Provided below are standard protocols that you may find useful for product applications.
Proteoglycans, which consist of a core protein and covalently linked glycosaminoglycans, are components of the extracellular matrix. SPOCK3 encodes a member of a novel Ca(2+)-binding proteoglycan family.
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Kamioka, M., et al. Leuk. Res. 33(7):913-918(2009)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Clark, H.F., et al. Genome Res. 13(10):2265-2270(2003)
Nakada, M., et al. Cancer Res. 61(24):8896-8902(2001)
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