|Application ||WB, E|
|Calculated MW||27562 Da|
|Antigen Region||10-36 aa|
|Other Names||Ras association domain-containing protein 3, RASSF3|
|Target/Specificity||This RASSF3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 10-36 amino acids from the N-terminal region of human RASSF3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||RASSF3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Cytoplasm. Cytoplasm, cytoskeleton Note=Localized to microtubules in vascular endothelial cells|
|Tissue Location||Widely expressed.|
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Provided below are standard protocols that you may find useful for product applications.
The RAS oncogene (MIM 190020) is mutated in nearly one-third of all human cancers. Members of the RAS superfamily are plasma membrane GTP-binding proteins that modulate intracellular signal transduction pathways. A subfamily of RAS effectors, including RASSF3, share a RAS association (RA) domain.[supplied by OMIM].
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Jacquemart, I.C., et al. Int. J. Oncol. 34(2):517-528(2009)
Fujita, H., et al. J. Biol. Chem. 280(6):5022-5031(2005)
Tommasi, S., et al. Oncogene 21(17):2713-2720(2002)
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