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RQCD1 Antibody (Center)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RQCD1 Antibody (Center) AP17848c
    RQCD1 Antibody (Center) (Cat. #AP17848c) western blot analysis in MDA-MB231 cell line lysates (35ug/lane).This demonstrates the RQCD1 antibody detected the RQCD1 protein (arrow).
  • WB - RQCD1 Antibody (Center) AP17848c
    RQCD1 Antibody (Center) (Cat. #AP17848c) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the RQCD1 antibody detected the RQCD1 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q92600
Other Accession Q6IP65, Q5PQL2, Q9JKY0, Q4R347, Q6NWL4, A7MB47, NP_005435.1
Reactivity Human, Mouse
Predicted Bovine, Zebrafish, Monkey, Rat, Xenopus
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 33631 Da
Antigen Region 106-134 aa
Additional Information
Gene ID 9125
Other Names Cell differentiation protein RCD1 homolog, Rcd-1, CCR4-NOT transcription complex subunit 9, RQCD1, CNOT9, RCD1
Target/Specificity This RQCD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 106-134 amino acids from the Central region of human RQCD1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRQCD1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RQCD1
Synonyms CNOT9, RCD1
Function Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all.
Cellular Location Nucleus. Cytoplasm, P-body. Note=NANOS2 promotes its localization to P-body
Tissue Location Detected in spleen, thymus, prostate, testis, ovary and intestine.
Citations (0)

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Background

Transcription factor that down-regulates MYB-and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A.

References

Ajiro, M., et al. Int. J. Oncol. 35(4):673-681(2009)
Miyasaka, T., et al. Cancer Sci. 99(4):755-761(2008)
Garapaty, S., et al. J. Biol. Chem. 283(11):6806-6816(2008)
Morita, M., et al. Mol. Cell. Biol. 27(13):4980-4990(2007)
Hiroi, N., et al. EMBO J. 21(19):5235-5244(2002)

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$ 295.00
$ 99.00
Cat# AP17848c
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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