|Application ||WB, E|
|Other Accession||Q8VE80, Q29RH4, NP_115737.1|
|Calculated MW||38772 Da|
|Antigen Region||71-98 aa|
|Other Names||THO complex subunit 3, Tho3, TEX1 homolog, hTREX45, THOC3|
|Target/Specificity||This THOC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-98 amino acids from the N-terminal region of human THOC3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||THOC3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.|
|Cellular Location||Nucleus. Nucleus speckle|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
TEX1 is part of the TREX (transcription/export) complex, which includes THO2 (MIM 300395), HPR1 (MIM 606930), ALY (MIM 604171), and UAP56 (MIM 142560).
Boyne, J.R., et al. PLoS Pathog. 4 (10), E1000194 (2008) :
Cheng, H., et al. Cell 127(7):1389-1400(2006)
Masuda, S., et al. Genes Dev. 19(13):1512-1517(2005)
Guo, S., et al. Cancer Res. 65(8):3011-3016(2005)
Strasser, K., et al. Nature 417(6886):304-308(2002)
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