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THOC3 Antibody (N-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - THOC3 Antibody (N-term) AP17859a
    THOC3 Antibody (N-term) (Cat. #AP17859a) western blot analysis in A2058 cell line lysates (35ug/lane).This demonstrates the THOC3 antibody detected the THOC3 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q96J01
Other Accession Q8VE80, Q29RH4, NP_115737.1
Reactivity Human
Predicted Bovine, Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 38772 Da
Antigen Region 71-98 aa
Additional Information
Gene ID 84321
Other Names THO complex subunit 3, Tho3, TEX1 homolog, hTREX45, THOC3
Target/Specificity This THOC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-98 amino acids from the N-terminal region of human THOC3.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsTHOC3 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name THOC3
Function Required for efficient export of polyadenylated RNA and spliced mRNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Cellular Location Nucleus. Nucleus speckle
Citations (0)

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TEX1 is part of the TREX (transcription/export) complex, which includes THO2 (MIM 300395), HPR1 (MIM 606930), ALY (MIM 604171), and UAP56 (MIM 142560).


Boyne, J.R., et al. PLoS Pathog. 4 (10), E1000194 (2008) :
Cheng, H., et al. Cell 127(7):1389-1400(2006)
Masuda, S., et al. Genes Dev. 19(13):1512-1517(2005)
Guo, S., et al. Cancer Res. 65(8):3011-3016(2005)
Strasser, K., et al. Nature 417(6886):304-308(2002)

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$ 295.00
$ 99.00
Cat# AP17859a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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