|Application ||WB, E|
|Other Accession||Q9D8C3, NP_001161857.1, NP_001034299.3|
|Calculated MW||126056 Da|
|Antigen Region||44-70 aa|
|Other Names||Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13, Asparagine-linked glycosylation 13 homolog, Glycosyltransferase 28 domain-containing protein 1, UDP-N-acetylglucosamine transferase subunit ALG13 homolog, ALG13, CXorf45, GLT28D1|
|Target/Specificity||This ALG13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 44-70 amino acids from the Central region of human ALG13.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ALG13 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Isoform 1: Possible multifunctional enzyme with both glycosyltransferase and deubiquitinase activities.|
|Cellular Location||Isoform 2: Endoplasmic reticulum. Note=Could be recruited to the cytosolic face of the endoplasmic reticulum membrane through its interaction with ALG14|
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Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a subunit of a bipartite UDP-N-acetylglucosamine transferase. It heterodimerizes with asparagine-linked glycosylation 14 homolog to form a functional UDP-GlcNAc glycosyltransferase that catalyzes the second sugar addition of the highly conserved oligosaccharide precursor in endoplasmic reticulum N-linked glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene.
Averbeck, N., et al. J. Biol. Chem. 282(40):29081-29088(2007)
Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)
Gao, X.D., et al. J. Biol. Chem. 280(43):36254-36262(2005)
Epplen, C., et al. Hum. Genet. 93(1):35-41(1994)
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