|Application ||WB, E|
|Other Accession||P29975, Q02013, P47865, NP_932766.1, P56401|
|Calculated MW||28526 Da|
|Antigen Region||241-269 aa|
|Other Names||Aquaporin-1, AQP-1, Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule, AQP1, CHIP28|
|Target/Specificity||This AQP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-269 amino acids from the C-terminal region of human AQP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||AQP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.|
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Provided below are standard protocols that you may find useful for product applications.
Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene.
Chen, L.M., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299 (5), R1163-R1174 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Shankardas, J., et al. Mol. Vis. 16, 1538-1548 (2010) :
Halverson, G.R., et al. Immunohematology 26(1):22-26(2010)
Sui, H., et al. Nature 414(6866):872-878(2001)
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