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AQP1 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - AQP1 Antibody (C-term) AP17893b
    AQP1 Antibody (C-term) (Cat. #AP17893b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the AQP1 antibody detected the AQP1 protein (arrow).
    detail
  • WB - AQP1 Antibody (C-term) AP17893b
    AQP1 Antibody (C-term) (Cat. #AP17893b) western blot analysis in mouse brain tissue lysates (35ug/lane).This demonstrates the AQP1 antibody detected the AQP1 protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession P29972
Other Accession P29975, Q02013, P47865, NP_932766.1, P56401
Reactivity Human, Mouse
Predicted Bovine, Rat, Sheep
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 28526 Da
Antigen Region 241-269 aa
Additional Information
Gene ID 358
Other Names Aquaporin-1, AQP-1, Aquaporin-CHIP, Urine water channel, Water channel protein for red blood cells and kidney proximal tubule, AQP1, CHIP28
Target/Specificity This AQP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-269 amino acids from the C-terminal region of human AQP1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsAQP1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name AQP1 (HGNC:633)
Synonyms CHIP28
Function Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (PubMed:1373524). Component of the ankyrin-1 complex, a multiprotein complex involved in the stability and shape of the erythrocyte membrane (PubMed:35835865).
Cellular Location Cell membrane; Multi-pass membrane protein
Tissue Location Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver
Research Areas
Citations (0)
citation

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Background

Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This gene encodes an aquaporin which functions as a molecular water channel protein. It is a homotetramer with 6 bilayer spanning domains and N-glycosylation sites. The protein physically resembles channel proteins and is abundant in erythrocytes and renal tubes. The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Several transcript variants encoding different isoforms have been found for this gene.

References

Chen, L.M., et al. Am. J. Physiol. Regul. Integr. Comp. Physiol. 299 (5), R1163-R1174 (2010) :
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Shankardas, J., et al. Mol. Vis. 16, 1538-1548 (2010) :
Halverson, G.R., et al. Immunohematology 26(1):22-26(2010)
Sui, H., et al. Nature 414(6866):872-878(2001)

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$ 182.50
$ 70.00
Cat# AP17893b
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