|Application ||WB, E|
|Calculated MW||52404 Da|
|Antigen Region||384-412 aa|
|Other Names||Paraneoplastic antigen Ma3, PNMA3, MA3|
|Target/Specificity||This PNMA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 384-412 amino acids from the C-terminal region of human PNMA3.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||PNMA3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Cellular Location||Nucleus, nucleolus.|
|Tissue Location||Expressed at high levels in the brain and testis. Expressed at lower levels in the heart, trachea and kidney.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the paraneoplastic antigen MA (PNMA) gene family, whose protein products share homology with retroviral Gag proteins. They are highly expressed in the brain and also in a range of tumors associated with serious neurological phenotypes. PMID:16407312 reports the presence of a functional -1 ribosomal frameshift signal (consisting of a heptanucleotide shift motif followed 3' by a pseudoknot structure) in this gene, however, the frame-shifted product has not been characterized. [provided by RefSeq].
Wills, N.M., et al. J. Biol. Chem. 281(11):7082-7088(2006)
Schuller, M., et al. J. Neuroimmunol. 169 (1-2), 172-176 (2005) :
Rosenfeld, M.R., et al. Ann. Neurol. 50(3):339-348(2001)
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