Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
Mouse Ryk Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q01887 |
| Other Accession | NP_001036072.1 |
| Reactivity | Human, Mouse |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 66285 Da |
| Antigen Region | 321-348 aa |
| Gene ID | 20187 |
|---|---|
| Other Names | Tyrosine-protein kinase RYK, Kinase VIK, Met-related kinase, NYK-R, Ryk, Mrk |
| Target/Specificity | This Mouse Ryk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-348 amino acids from the Central region of mouse Ryk. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | Mouse Ryk Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | Ryk |
|---|---|
| Synonyms | Mrk |
| Function | May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C-terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development. |
| Cellular Location | Membrane; Single- pass type I membrane protein. Nucleus. Cytoplasm Note=In cells that have undergone neuronal differentiation, the C- terminal cleaved part is translocated from the cytoplasm to the nucleus |
| Tissue Location | Is detected in all the tissues. Highest levels are seen in the ovary, lung and placenta |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
Ryk is potential growth factor receptor protein tyrosine kinase.
References
Buchert, M., et al. PLoS Genet. 6 (1), E1000816 (2010) :
Lyu, J., et al. Dev. Cell 15(5):773-780(2008)
Tamplin, O.J., et al. BMC Genomics 9, 511 (2008) :
Keeble, T.R., et al. J. Neurosci. 26(21):5840-5848(2006)
Schmitt, A.M., et al. Nature 439(7072):31-37(2006)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
