|Application ||WB, E|
|Calculated MW||66285 Da|
|Antigen Region||321-348 aa|
|Other Names||Tyrosine-protein kinase RYK, Kinase VIK, Met-related kinase, NYK-R, Ryk, Mrk|
|Target/Specificity||This Mouse Ryk antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 321-348 amino acids from the Central region of mouse Ryk.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||Mouse Ryk Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||May be a coreceptor along with FZD8 of Wnt proteins, such as WNT1, WNT3, WNT3A and WNT5A. Involved in neuron differentiation, axon guidance, corpus callosum establishment and neurite outgrowth. In response to WNT3 stimulation, receptor C- terminal cleavage occurs in its transmembrane region and allows the C-terminal intracellular product to translocate from the cytoplasm to the nucleus where it plays a crucial role in neuronal development.|
|Cellular Location||Membrane; Single-pass type I membrane protein Nucleus. Cytoplasm. Note=In cells that have undergone neuronal differentiation, the C-terminal cleaved part is translocated from the cytoplasm to the nucleus|
|Tissue Location||Is detected in all the tissues. Highest levels are seen in the ovary, lung and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Ryk is potential growth factor receptor protein tyrosine kinase.
Buchert, M., et al. PLoS Genet. 6 (1), E1000816 (2010) :
Lyu, J., et al. Dev. Cell 15(5):773-780(2008)
Tamplin, O.J., et al. BMC Genomics 9, 511 (2008) :
Keeble, T.R., et al. J. Neurosci. 26(21):5840-5848(2006)
Schmitt, A.M., et al. Nature 439(7072):31-37(2006)
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