|Application ||WB, E|
|Other Accession||Q9EPX5, NP_060173.1|
|Calculated MW||37026 Da|
|Antigen Region||277-303 aa|
|Other Names||F-box/LRR-repeat protein 12, F-box and leucine-rich repeat protein 12, F-box protein FBL12, FBXL12, FBL12|
|Target/Specificity||This FBXL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-303 amino acids from the C-terminal region of human FBXL12.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXL12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.|
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Provided below are standard protocols that you may find useful for product applications.
Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)
Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999)
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