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>   home   >   Products   >   Primary Antibodies   >   Cell Biology   >   FBXL12 Antibody (C-term)   

FBXL12 Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - FBXL12 Antibody (C-term) AP17921b
    FBXL12 Antibody (C-term) (Cat. #AP17921b) western blot analysis in SK-BR-3 cell line lysates (35ug/lane).This demonstrates the FBXL12 antibody detected the FBXL12 protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q9NXK8
Other Accession Q9EPX5, NP_060173.1
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 37026 Da
Antigen Region 277-303 aa
Additional Information
Gene ID 54850
Other Names F-box/LRR-repeat protein 12, F-box and leucine-rich repeat protein 12, F-box protein FBL12, FBXL12, FBL12
Target/Specificity This FBXL12 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 277-303 amino acids from the C-terminal region of human FBXL12.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsFBXL12 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name FBXL12
Synonyms FBL12
Function Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.
Research Areas
Citations (0)

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Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM].


Lamesch, P., et al. Genomics 89(3):307-315(2007)
Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Jin, J., et al. Genes Dev. 18(21):2573-2580(2004)
Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999)

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$ 295.00
$ 99.00
Cat# AP17921b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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