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PVRL4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q96NY8 |
| Other Accession | NP_112178.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 55454 Da |
| Antigen Region | 239-266 aa |
| Gene ID | 81607 |
|---|---|
| Other Names | Nectin-4, Ig superfamily receptor LNIR, Poliovirus receptor-related protein 4, Processed poliovirus receptor-related protein 4, PVRL4, LNIR, PRR4 |
| Target/Specificity | This PVRL4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-266 amino acids from the Central region of human PVRL4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | PVRL4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | NECTIN4 (HGNC:19688) |
|---|---|
| Synonyms | LNIR, PRR4, PVRL4 |
| Function | Seems to be involved in cell adhesion through trans- homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Cell junction, adherens junction. Note=Colocalizes with AFDN at cadherin- based adherens junctions (PubMed:11544254) |
| Tissue Location | Predominantly expressed in placenta. Not detected in normal breast epithelium but expressed in breast carcinoma |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Poliovirus receptor-like proteins (PVRLs), such as PVRL4, are adhesion receptors of the immunoglobulin superfamily and function in cell-cell adhesion (Reymond et al., 2001 [PubMed 11544254]).
References
Derycke, M.S., et al. Am. J. Clin. Pathol. 134(5):835-845(2010)
Brancati, F., et al. Am. J. Hum. Genet. 87(2):265-273(2010)
Takano, A., et al. Cancer Res. 69(16):6694-6703(2009)
Fabre-Lafay, S., et al. BMC Cancer 7, 73 (2007) :
Fabre-Lafay, S., et al. J. Biol. Chem. 280(20):19543-19550(2005)
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