|Application ||WB, E|
|Other Accession||Q6GR10, Q5RKJ1, Q4VC33, Q4R9A8, Q7SXR3, Q5F398, Q3MHJ2, NP_001017405.1, NP_005873.2|
|Predicted||Bovine, Chicken, Zebrafish, Monkey, Mouse, Rat, Xenopus|
|Calculated MW||45287 Da|
|Antigen Region||16-42 aa|
|Other Names||Macrophage erythroblast attacher, Cell proliferation-inducing gene 5 protein, Erythroblast macrophage protein, Human lung cancer oncogene 10 protein, HLC-10, MAEA, EMP|
|Target/Specificity||This MAEA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-42 amino acids from the N-terminal region of human MAEA.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||MAEA Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events.|
|Cellular Location||Nucleus matrix. Cell membrane. Cytoplasm, cytoskeleton. Note=Localized as nuclear speckled- like pattern|
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Provided below are standard protocols that you may find useful for product applications.
This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Two immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of 33 kD and 36 kD were detected in macrophage membranes; this gene encodes the larger isoform. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined.
Kobayashi, N., et al. Gene 396(2):236-247(2007)
Bala, S., et al. Biochem. Biophys. Res. Commun. 342(4):1040-1048(2006)
Hanspal, M., et al. Blood 92(8):2940-2950(1998)
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