|Application ||WB, E|
|Calculated MW||40516 Da|
|Antigen Region||57-83 aa|
|Other Names||F-box/LRR-repeat protein 8, F-box and leucine-rich repeat protein 8, F-box protein FBL8, FBXL8, FBL8|
|Target/Specificity||This FBXL8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 57-83 amino acids from the N-terminal region of human FBXL8.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||FBXL8 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Lievens, S., et al. J. Proteome Res. 8(2):877-886(2009)
Winston, J.T., et al. Curr. Biol. 9(20):1180-1182(1999)
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