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RAB2B Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - RAB2B Antibody (Center) AP17933c
    RAB2B Antibody (Center) (Cat. #AP17933c) western blot analysis in A375 cell line lysates (35ug/lane).This demonstrates the RAB2B antibody detected the RAB2B protein (arrow).
    detail
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q8WUD1
Other Accession P59279, NP_116235.2
Reactivity Human
Predicted Mouse
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 24214 Da
Antigen Region 105-131 aa
Additional Information
Gene ID 84932
Other Names Ras-related protein Rab-2B, RAB2B
Target/Specificity This RAB2B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 105-131 amino acids from the Central region of human RAB2B.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsRAB2B Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name RAB2B (HGNC:20246)
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between active GTP-bound and inactive GDP-bound states. In their active state, drive transport of vesicular carriers from donor organelles to acceptor organelles to regulate the membrane traffic that maintains organelle identity and morphology. Regulates the compacted morphology of the Golgi (Probable). Promotes cytosolic DNA-induced innate immune responses. Regulates IFN responses against DNA viruses by regulating the CGAS-STING signaling axis (By similarity).
Cellular Location Cell membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}; Cytoplasmic side {ECO:0000250|UniProtKB:P59279}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}. Golgi apparatus membrane {ECO:0000250|UniProtKB:P59279}; Lipid-anchor {ECO:0000250|UniProtKB:P59279}. Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000250|UniProtKB:P59279}. Note=Localized in the Golgi apparatus in the round spermatids and in the acrosome in the elongating spermatid. {ECO:0000250|UniProtKB:P59279}
Tissue Location Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte
Research Areas
Citations (0)
citation

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Background

Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM].

References

Barrios-Rodiles, M., et al. Science 307(5715):1621-1625(2005)
Fu, G.K., et al. Genomics 84(1):205-210(2004)
Ni, X., et al. J. Hum. Genet. 47(10):548-551(2002)

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$ 365.00
$ 140.00
Cat# AP17933c
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