SEPT10 Antibody (N-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9P0V9 |
Other Accession | NP_653311.1, NP_848699.1 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 52593 Da |
Antigen Region | 14-40 aa |
Gene ID | 151011 |
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Other Names | Septin-10, SEPT10 |
Target/Specificity | This SEPT10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-40 amino acids from the N-terminal region of human SEPT10. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | SEPT10 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | SEPTIN10 (HGNC:14349) |
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Synonyms | SEPT10 |
Function | Filament-forming cytoskeletal GTPase. May play a role in cytokinesis (Potential). |
Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q8C650}. Note=Detected in the annulus of the sperm flagellum and in the neck region in spermatids and mature sperm (By similarity). Using a GFP-fusion protein, detected in the nucleus. {ECO:0000250|UniProtKB:Q8C650, ECO:0000269|PubMed:12711328} |
Tissue Location | Widely expressed. Abundantly expressed in heart and kidney, placenta, skeletal muscles, liver and lung, as well as various tumor cell lines. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the septin family of cytoskeletal proteins with GTPase activity. This protein localizes to the cytoplasm and nucleus and displays GTP-binding and GTPase activity. Alternate splicing results in two transcript variants encoding different isoforms.
References
Benedetti, D., et al. Leukemia 22(1):224-226(2008)
Lamesch, P., et al. Genomics 89(3):307-315(2007)
Hillier, L.W., et al. Nature 434(7034):724-731(2005)
Sui, L., et al. Biochem. Biophys. Res. Commun. 304(2):393-398(2003)
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