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BEX4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9NWD9 |
| Other Accession | NP_001121160.1 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 14067 Da |
| Antigen Region | 54-82 aa |
| Gene ID | 56271 |
|---|---|
| Other Names | Protein BEX4, BEX1-like protein 1, Brain-expressed X-linked protein 4, Nerve growth factor receptor-associated protein 3, BEX4, BEXL1, NADE3 |
| Target/Specificity | This BEX4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-82 amino acids from the Central region of human BEX4. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | BEX4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BEX4 {ECO:0000303|PubMed:15958283, ECO:0000312|HGNC:HGNC:25475} |
|---|---|
| Function | May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability (PubMed:27512957). In absence of reductive stress, acts as a pseudosubstrate for the CRL2(FEM1B) complex: associates with FEM1B via zinc, thereby preventing association between FEM1B and its substrates (By similarity). |
| Cellular Location | Cytoplasm, cytoskeleton, spindle pole. Nucleus Cytoplasm. Note=Also localizes to microtubules. |
| Tissue Location | Very high expression in heart, skeletal muscle, liver, and kidney. The levels of expression are uniform throughout the brain. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Bex proteins are expressed from a family of "brain expressed X-linked genes".
References
Alvarez, E., et al. Gene 357(1):18-28(2005)
Ross, M.T., et al. Nature 434(7031):325-337(2005)
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