CPNE5 Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q9HCH3 |
Other Accession | Q8JZW4, NP_065990.1 |
Reactivity | Human |
Predicted | Mouse |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 65734 Da |
Antigen Region | 509-535 aa |
Gene ID | 57699 |
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Other Names | Copine-5, Copine V, CPNE5, KIAA1599 |
Target/Specificity | This CPNE5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 509-535 amino acids from the C-terminal region of human CPNE5. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | CPNE5 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | CPNE5 (HGNC:2318) |
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Function | Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). |
Cellular Location | Perikaryon {ECO:0000250|UniProtKB:Q8JZW4}. Cell projection {ECO:0000250|UniProtKB:Q8JZW4} |
Tissue Location | Expressed in the brain, heart, stomach, spleen, lymph node and testis (PubMed:12949241). Expressed in melanocytes (PubMed:23999003). |
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Provided below are standard protocols that you may find useful for product applications.
Background
Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. Sequence analysis identified multiple alternatively spliced transcript variants but their full-length natures could not be determined.
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Mungall, A.J., et al. Nature 425(6960):805-811(2003)
Tripodis, N., et al. Genome Res. 8(6):631-643(1998)
Creutz, C.E., et al. J. Biol. Chem. 273(3):1393-1402(1998)
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