GBP4 Antibody (Center)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application
| WB, E |
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Primary Accession | Q96PP9 |
Other Accession | NP_443173.2 |
Reactivity | Human |
Host | Rabbit |
Clonality | Polyclonal |
Isotype | Rabbit IgG |
Calculated MW | 73165 Da |
Antigen Region | 370-396 aa |
Gene ID | 115361 |
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Other Names | Guanylate-binding protein 4, GTP-binding protein 4, GBP-4, Guanine nucleotide-binding protein 4, GBP4 |
Target/Specificity | This GBP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 370-396 amino acids from the Central region of human GBP4. |
Dilution | WB~~1:1000 |
Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
Precautions | GBP4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures. |
Name | GBP4 {ECO:0000303|Ref.1, ECO:0000312|HGNC:HGNC:20480} |
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Function | Interferon (IFN)-inducible GTPase that plays important roles in innate immunity against a diverse range of bacterial, viral and protozoan pathogens (By similarity). Negatively regulates the antiviral response by inhibiting activation of IRF7 transcription factor (By similarity). |
Cellular Location | Golgi apparatus membrane. Cytoplasm Nucleus. Cytoplasm, perinuclear region. Note=Heterodimers with GBP1, GBP2 and GBP5 localize in the compartment of the prenylated GBPs: with GBP1 in a vesicle-like compartment, with GBP2, around the nucleus and with GBP5, at the Golgi apparatus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).
References
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Olszewski, M.A., et al. J. Interferon Cytokine Res. 26(5):328-352(2006)
Vestal, D.J. J. Interferon Cytokine Res. 25(8):435-443(2005)
Han, B.H., et al. Biochim. Biophys. Acta 1384(2):373-386(1998)
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