|Application ||WB, E|
|Calculated MW||73165 Da|
|Antigen Region||370-396 aa|
|Other Names||Guanylate-binding protein 4, GTP-binding protein 4, GBP-4, Guanine nucleotide-binding protein 4, GBP4|
|Target/Specificity||This GBP4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 370-396 amino acids from the Central region of human GBP4.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GBP4 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Binds GTP, GDP and GMP. Hydrolyzes GTP very efficiently; GDP rather than GMP is the major reaction product. Plays a role in erythroid differentiation (By similarity).|
|Cellular Location||Cytoplasm. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
Guanylate-binding proteins, such as GBP4, are induced by interferon and hydrolyze GTP to both GDP and GMP (Vestal, 2005 [PubMed 16108726]).
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Olszewski, M.A., et al. J. Interferon Cytokine Res. 26(5):328-352(2006)
Vestal, D.J. J. Interferon Cytokine Res. 25(8):435-443(2005)
Han, B.H., et al. Biochim. Biophys. Acta 1384(2):373-386(1998)
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