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IFT27 Antibody (C-term)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - IFT27 Antibody (C-term) AP17978b
    IFT27 Antibody (C-term) (Cat. #AP17978b) western blot analysis in A549 cell line lysates (35ug/lane).This demonstrates the IFT27 antibody detected the IFT27 protein (arrow).
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9BW83
Other Accession NP_001171172.1
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 20480 Da
Antigen Region 157-183 aa
Additional Information
Gene ID 11020
Other Names Intraflagellar transport protein 27 homolog, Putative GTP-binding protein RAY-like, Rab-like protein 4, IFT27, RABL4, RAYL
Target/Specificity This IFT27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-183 amino acids of human IFT27.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsIFT27 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name IFT27
Synonyms RABL4, RAYL
Function Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25. Its role in intraflagellar transport is mainly seen in tissues rich in ciliated cells such as kidney and testis. Essential for male fertility, spermiogenesis and sperm flagella formation. Plays a role in the early development of the kidney. May be involved in the regulation of ureteric bud initiation (By similarity).
Cellular Location Cell projection, cilium. Cytoplasm {ECO:0000250|UniProtKB:Q9D0P8}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q9D0P8}. Note=Localizes to the sperm flagellum {ECO:0000250|UniProtKB:Q9D0P8}
Research Areas
Citations (0)
citation

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Background

This gene encodes a putative GTP-binding protein similar to RAY/RAB1C. The protein is ras-related, but the function is unknown. Several transcript variants encoding different isoforms have been found for this gene.

References

Qin, H., et al. Curr. Biol. 17(3):193-202(2007)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Collins, J.E., et al. Genome Res. 13(1):27-36(2003)
Dunham, I., et al. Nature 402(6761):489-495(1999)

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Discontinued
Cat# AP17978b
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