|Application ||WB, E|
|Calculated MW||20480 Da|
|Antigen Region||157-183 aa|
|Other Names||Intraflagellar transport protein 27 homolog, Putative GTP-binding protein RAY-like, Rab-like protein 4, IFT27, RABL4, RAYL|
|Target/Specificity||This IFT27 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 157-183 amino acids from the C-terminal region of human IFT27.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||IFT27 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 (PubMed:25443296). Not involved in entry of the BBSome complex into cilium. Prevents aggregation of GTP-free ARL6 (PubMed:25443296). Required for hedgehog signaling. Forms a subcomplex within the IFT complex B with IFT25 (By similarity).|
|Cellular Location||Cell projection, cilium|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a putative GTP-binding protein similar to RAY/RAB1C. The protein is ras-related, but the function is unknown. Several transcript variants encoding different isoforms have been found for this gene.
Qin, H., et al. Curr. Biol. 17(3):193-202(2007)
Collins, J.E., et al. Genome Biol. 5 (10), R84 (2004) :
Collins, J.E., et al. Genome Res. 13(1):27-36(2003)
Dunham, I., et al. Nature 402(6761):489-495(1999)
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