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CENPE Antibody (C-term)

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

  • WB - CENPE Antibody (C-term) AP17985b
    CENPE Antibody (C-term) (Cat. #AP17985b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the CENPE antibody detected the CENPE protein (arrow).
Product Information
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
Primary Accession Q02224
Other Accession NP_001804
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit Ig
Calculated MW 316415 Da
Antigen Region 2573-2601 aa
Additional Information
Gene ID 1062
Other Names Centromere-associated protein E, Centromere protein E, CENP-E, Kinesin-related protein CENPE, CENPE
Target/Specificity This CENPE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 2573-2601 amino acids from the C-terminal region of human CENPE.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsCENPE Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Function Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during mitosis. Is a slow plus end- directed motor whose activity is essential for metaphase chromosome alignment. Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule- dependent motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity. Accumulates just before mitosis at the G2 phase of the cell cycle.
Cellular Location Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Associates with kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is quantitatively discarded at the end of the cell division
Citations (0)

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Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.


Kim, Y., et al. Cell 142(3):444-455(2010)
Maia, A.F., et al. Chromosoma 119(4):405-413(2010)
Kalsi, G., et al. Hum. Mol. Genet. 19(12):2497-2506(2010)
Maffini, S., et al. Curr. Biol. 19(18):1566-1572(2009)
Liu, Z., et al. J. Exp. Clin. Cancer Res. 28, 156 (2009) :

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Cat# AP17985b
(40 western blots)
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