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DLEC1 Antibody (Center)

Affinity Purified Rabbit Polyclonal Antibody (Pab)

     
  • WB - DLEC1 Antibody (Center) AP17986c
    Anti-DLEC1 Antibody (Center) at 1:1000 dilution + human testis lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 196 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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Product Information
Application
  • Applications Legend:
  • WB=Western Blot
  • IHC=Immunohistochemistry
  • IHC-P=Immunohistochemistry (Paraffin-embedded Sections)
  • IHC-F=Immunohistochemistry (Frozen Sections)
  • IF=Immunofluorescence
  • FC=Flow Cytopmetry
  • IC=Immunochemistry
  • ICC=Immunocytochemistry
  • E=ELISA
  • IP=Immunoprecipitation
  • DB=Dot Blot
  • CHIP=Chromatin Immunoprecipitation
  • FA=Fluorescence Assay
  • IEM=Immunoelectronmicroscopy
  • EIA=Enzyme Immunoassay
WB, E
Primary Accession Q9Y238
Other Accession NP_031361
Reactivity Human
Host Rabbit
Clonality Polyclonal
Isotype Rabbit IgG
Calculated MW 195684 Da
Antigen Region 879-908 aa
Additional Information
Gene ID 9940
Other Names Deleted in lung and esophageal cancer protein 1, Deleted in lung cancer protein 1, DLC-1, DLEC1 {ECO:0000312|EMBL:BAA776241}
Target/Specificity This DLEC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 879-908 amino acids from the Central region of human DLEC1.
Dilution WB~~1:1000
Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
StorageMaintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
PrecautionsDLEC1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
Protein Information
Name DLEC1 {ECO:0000312|EMBL:BAA77624.1}
Function Essential for spermatogenesis and male fertility (By similarity). May play an important role in sperm head and tail formation (By similarity). May act as a tumor suppressor by inhibiting cell proliferation.
Cellular Location Cytoplasm
Tissue Location Expressed in all tissues examined. Expression is highest in prostate and testis.
Research Areas
Citations (0)
citation

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Background

This gene contains 37 exons, spans approximately 59-kb, and is located in the 3p22-p21.3 chromosomal segment that is commonly deleted in various carcinomas. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins. Aberrant transcription of this gene may be involved in carcinogenesis of the lung, esophagus, and kidney.

References

Zhang, Q., et al. J. Urol. 184(2):731-737(2010)
Zhang, Y., et al. Clin Lung Cancer 11(4):264-270(2010)
Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :
Al Sarakbi, W., et al. Anticancer Res. 30(4):1079-1082(2010)
Canova, C., et al. Cancer Res. 69(7):2956-2965(2009)

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$ 182.50
$ 70.00
Cat# AP17986c
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