|Application ||WB, E|
|Calculated MW||15865 Da|
|Antigen Region||15-42 aa|
|Other Names||ADM2, Intermedin, Adrenomedullin-2, AM2, Intermedin-long, IMDL, Intermedin-short, IMDS, ADM2, AM2|
|Target/Specificity||This ADM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 15-42 amino acids from the N-terminal region of human ADM2.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||ADM2 Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||IMDL and IMDS may play a role as physiological regulators of gastrointestinal, cardiovascular bioactivities mediated by the CALCRL/RAMPs receptor complexes. Activates the cAMP-dependent pathway.|
|Tissue Location||Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary|
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Provided below are standard protocols that you may find useful for product applications.
ADM2 belongs to a family of calcitonin (MIM 114130)-related peptide hormones important for regulating diverse physiologic functions and the chemical composition of fluids and tissues.
Cai, Y., et al. Cardiovasc. Res. 85(4):864-873(2010)
Pfeil, U., et al. Am. J. Physiol. Lung Cell Mol. Physiol. 297 (5), L837-L845 (2009) :
Chauhan, M., et al. Biol. Reprod. 81(4):777-783(2009)
Smith, R.S. Jr., et al. Am. J. Physiol. Heart Circ. Physiol. 297 (3), H1040-H1047 (2009) :
Pearson, L.J., et al. Cell. Physiol. Biochem. 23 (1-3), 97-108 (2009) :
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