|Application ||WB, E|
|Calculated MW||46482 Da|
|Antigen Region||91-119 aa|
|Other Names||Golgi reassembly-stacking protein 1, Golgi peripheral membrane protein p65, Golgi phosphoprotein 5, GOLPH5, Golgi reassembly-stacking protein of 65 kDa, GRASP65, GORASP1, GOLPH5, GRASP65|
|Target/Specificity||This GORASP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 91-119 amino acids from the Central region of human GORASP1.|
|Format||Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.|
|Storage||Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.|
|Precautions||GORASP1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.|
|Function||Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity). Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344).|
|Cellular Location||Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein; Cytoplasmic side. Note=Undergoes rapid exchange with the cytosol.|
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Provided below are standard protocols that you may find useful for product applications.
The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgi apparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgi matrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Several alternatively spliced transcript variants of this gene have been identified, but their full-length natures have not been determined.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Tang, D., et al. Traffic 11(6):827-842(2010)
Xiang, Y., et al. J. Cell Biol. 188(2):237-251(2010)
D'Angelo, G., et al. J. Biol. Chem. 284(50):34849-34860(2009)
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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