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DMGDH Antibody (C-term)
Affinity Purified Rabbit Polyclonal Antibody (Pab)
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| WB, E |
|---|---|
| Primary Accession | Q9UI17 |
| Other Accession | NP_037523.2 |
| Reactivity | Human |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | Rabbit IgG |
| Calculated MW | 96811 Da |
| Antigen Region | 836-864 aa |
| Gene ID | 29958 |
|---|---|
| Other Names | Dimethylglycine dehydrogenase, mitochondrial, ME2GLYDH, DMGDH |
| Target/Specificity | This DMGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 836-864 amino acids from the C-terminal region of human DMGDH. |
| Dilution | WB~~1:1000 |
| Format | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. |
| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
| Precautions | DMGDH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | DMGDH |
|---|---|
| Function | Catalyzes the demethylation of N,N-dimethylglycine to sarcosine. Also has activity with sarcosine in vitro. |
| Cellular Location | Mitochondrion. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum.
References
Mostowska, A., et al. Eur. J. Oral Sci. 118(4):325-332(2010)
Bailey, S.D., et al. Diabetes Care (2010) In press :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)
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