|Application ||WB, E|
|Calculated MW||96811 Da|
|Antigen Region||836-864 aa|
|Other Names||Dimethylglycine dehydrogenase, mitochondrial, ME2GLYDH, DMGDH|
|Target/Specificity||This DMGDH antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 836-864 amino acids from the C-terminal region of human DMGDH.|
|Precautions||DMGDH Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes an enzyme involved in the catabolism of choline, catalyzing the oxidative demethylation of dimethylglycine to form sarcosine. The enzyme is found as a monomer in the mitochondrial matrix, and uses flavin adenine dinucleotide and folate as cofactors. Mutation in this gene causes dimethylglycine dehydrogenase deficiency, characterized by a fishlike body odor, chronic muscle fatigue, and elevated levels of the muscle form of creatine kinase in serum.
Mostowska, A., et al. Eur. J. Oral Sci. 118(4):325-332(2010)
Bailey, S.D., et al. Diabetes Care (2010) In press :
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
Boyles, A.L., et al. Genet. Epidemiol. 33(3):247-255(2009)
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